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Objectives

The purpose of this study is to investigate the adherence to the trial protocol in a multi-centre multinational setting as a pilot project for a large randomized controlled trial (feasibility trial).

Primary outcome: cardiovascular, AKI bundle fulfilled at all time.

 

Study design

PrevAKI II is a combination of an observational trial with a multicenter, prospective, randomized controlled, parallel-group, clinical trial.

 

Inclusion criteria

  1. Adult patients undergoing cardiac surgery with CPB
  2. Urinary [TIMP-2]*[IGFBP7] ≥ 0.3 4h after CPB
  3. Age between 18-90 years
  4. Written informed consent

 

Exclusion criteria

  1. Preexisting AKI (stage 1 and higher)
  2. Patients with cardiac assist devices (ECMO, LVAD, RVAD, IABP)
  3. Pregnancy, breastfeeding
  4. Known (Glomerulo-) Nephritis, interstitial nephritis or vasculitis
  5. CKD with eGFR < 20 ml/min
  6. Dialysis dependent CKD
  7. Prior kidney transplant within the last 12 months
  8. Participation in another intervention trial in the past 3 months
  9. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
  10. Persons held in an institution by legal or official order

 

For further information, please contact aki@anit.uni-muenster.de