> Research > Clinical Trial Network > SQUEEZE Study

Latest news

  • SQUEEZE study Protocol has been published in Perioperative Medicine.
  • SQUEEZE Recruitment will end 30th June 2023
  • We started data cleaning. For that purpose, we will need your help. Please can you check whenever possible if you have new queries to resolve for your centre in OpenClinica

Dear investigator,

Thank you for your interest in the SQUEEZE Study.

Chief Investigators

  • Dr. Ib JAMMER (Haukeland University Hospital – Bergen, Norway)
  • Dr. Ben Creagh-Brown (Royal Surrey County Hospital NHS Foundation Trust – Guildford
    d, United Kingdom)

Steering Committee

Lui Forni (UK), Ramani Moonesinghe (UK) and Hannah Wunsch (Canada), Peter Martin (UK).

The ESAIC Secretariat and Steering Committee are looking for National Coordinating Investigator to support the conduction of SQUEEZE study, if you are interested, please contact us at SQUEEZE@esaic.org.

Sponsor

The Study is entirely sponsored by a grant from the European Society of Anaesthesiology and Intensive Care Clinical Trial Network (ESAIC CTN). The aim of the European Society of Anaesthesiology and Intensive Care Clinical Trial Network is to provide an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.

The study is endorsed by the European Society of Intensive Care Medicine (ESICM).

Participating Countries

Objective

  • To evaluate the proportion of non-cardiac surgical patients receiving postoperative vasopressors.
  • To evaluate the characteristics of patients, surgery and anaesthesia that lead to postoperative vasopressor use.
  • To evaluate the incidence of organ injury in patients who receive postoperative vasopressors
  • To evaluate the variability in postoperative vasopressor use across healthcare environments.

Medical Problem

In the era of goal-directed fluid therapy and increasing popularity of restrictive fluid resuscitation, patients may be receiving less intravenous fluid and receiving more infused vasopressors to maintain adequate blood pressure.

There is anecdotal evidence of substantial variation in the management of post-operative hypotension between centres, countries and continents. The variation is in assessment (cardiac output and invasive monitoring) and environment (post-operative care units, high-dependency units, ICUs) and management (use and choice of fluids and vasopressors/inotropes).

In critically ill populations, receipt of infused vasopressors is associated with organ dysfunction, it has not been established if this relationship is true in postoperative populations.

Outcome Measures

  • Incidence of vasopressor use, and elucidation of risk factors
  • Postoperative organ dysfunction in patients receiving infused vasopressors.

 Timeline

  • Study selected by ESAIC Research Committee: April 2018
  • Call for centres: Ongoing

Join the study

This study will recruit as many participating institutions as possible. It is the plan to recruit at least 40,000 patients.

Would your hospital like to join this study as an actively contributing research centre? The ‘Call for Centres form’ must be filled in online. The completion of this form will facilitate coordination and is mandatory for participation in ESAIC CTN. ESAIC Secretariat will then contact you providing you with additional information.

Please visit the call for centres page.

Contact us

European Society of Anaesthesiology and Intensive Care

Rue des Comédiens 24
1000 Brussels, Belgium
T: +32 2 743 32 94 / +32 2 210 94 14
F: +32 2 743 32 98
E: research@esaic.org