Latest news

  • SQUEEZE protocol has been amended from version 1.12 dated 11 June 2020 to SQUEEZE Protocol version 2.0 dated 06 April 2021. Please send us the protocol signature page. Depending on local regulations, could you please either submit the protocol (and synopsis) to the Ethics Committee as an amendment OR inform the Ethics Committee of the change and ask for an acknowledgement of receipt.
  • Chief Investigators have agreed that all centres in the same country should not start at the same moment. Therefore, if you are ready, please let us know when would be your starting date by email at
  • Cohort A must be included within the year of participation. Therefore, you could start recruitment of cohort B and when COVID situation is calmer, or if you have a busy week planned, you can include Cohort A within Cohort B.
  • We started data cleaning. For that purpose, we will need your help. Please can you check whenever possible if you have new queries to resolve for your centre in OpenClinica

Dear investigator,

Thank you for your interest in the SQUEEZE Study. Prior recruitment, there are several steps to complete. Once all the steps are final and we are aware of your starting date, we will send you the access for the eCRF in OpenClinica.

NOTE : Principal Investigator must be a qualified doctor and all documents must be signed by the PI.

Mandatory steps before starting recruitment :

  1. Be listed on the list of participating Centres
  2. Complete the pre-study survey (1x per site)
  3. Use validated patient docs Translation – if your country is not in there, or you are missing a document, please contact your National Coordinator.
  4. Approval docs : Each centre must send 2 things :
    1. Approval Coversheet and
    2. Letter of approval/notification receipt from ethics/local authorizing body available
  1. Send eCRF users list: Max 3 persons with eCRF profiles per hospital. Investigator profile + 2 additional collaborators (provide first name, last name and email addresses)
  1. Sign the protocol : sign the page 3
  1. Sign the Data Processing/Transfer Agreement : Please contact us to have the specific document required for your country


Chief Investigators

  • Dr. Ib JAMMER (Haukeland University Hospital – Bergen, Norway)
  • Dr. Ben Creagh-Brown (Royal Surrey County Hospital NHS Foundation Trust – Guildford
    d, United Kingdom)

Steering Committee

Lui Forni (UK), Ramani Moonesinghe (UK) and Hannah Wunsch (Canada), Anil Gupta (Sweden), Peter Martin (UK).

The ESAIC Secretariat and Steering Committee are looking for National Coordinating Investigator to support the conduction of SQUEEZE study, if you are interested, please contact us at


The Study is entirely sponsored by a grant from the European Society of Anaesthesiology and Intensive Care Clinical Trial Network (ESAIC CTN). The aim of the European Society of Anaesthesiology and Intensive Care Clinical Trial Network is to provide an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.

The study is endorsed by the European Society of Intensive Care Medicine (ESICM).

Participating Countries


  • To evaluate the proportion of non-cardiac surgical patients receiving postoperative vasopressors.
  • To evaluate the characteristics of patients, surgery and anaesthesia that lead to postoperative vasopressor use.
  • To evaluate the incidence of organ injury in patients who receive postoperative vasopressors
  • To evaluate the variability in postoperative vasopressor use across healthcare environments.

Medical Problem

In the era of goal-directed fluid therapy and increasing popularity of restrictive fluid resuscitation, patients may be receiving less intravenous fluid and receiving more infused vasopressors to maintain adequate blood pressure.

There is anecdotal evidence of substantial variation in the management of post-operative hypotension between centres, countries and continents. The variation is in assessment (cardiac output and invasive monitoring) and environment (post-operative care units, high-dependency units, ICUs) and management (use and choice of fluids and vasopressors/inotropes).

In critically ill populations, receipt of infused vasopressors is associated with organ dysfunction, it has not been established if this relationship is true in postoperative populations.

Outcome Measures

  • Incidence of vasopressor use, and elucidation of risk factors
  • Postoperative organ dysfunction in patients receiving infused vasopressors.


  • Study selected by ESAIC Research Committee: April 2018
  • Call for centres: Ongoing

Join the study

This study will recruit as many participating institutions as possible. It is the plan to recruit at least 40,000 patients.

Would your hospital like to join this study as an actively contributing research centre? The ‘Call for Centres form’ must be filled in online. The completion of this form will facilitate coordination and is mandatory for participation in ESAIC CTN. ESAIC Secretariat will then contact you providing you with additional information.

Please visit the call for centres page.

Contact us

European Society of Anaesthesiology and Intensive Care

Rue des Comédiens 24
1000 Brussels, Belgium
T: +32 2 743 32 94 / +32 2 210 94 14
F: +32 2 743 32 98