Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE), Disma N et al. Br J Anaesth. 2021 Jun;126(6):1157-1172. 

Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study, Disma N et al. Br J Anaesth. 2021 Jun;126(6):1173-1181. 

Study selected by ESAIC Research Committee:2014 

Study protocol v1.0:28 August 2015 

Study CRF v1.2:11FEB2016 

Recruitment of patients:March 2016 – January 2017 

Paper Submission: August 2020 

Paper Publication: June 2021 


The aims of the NECTARINE study are:

  • Provide information on morbidity and mortality related to neonatal anaesthesia
  • Provide valuable information on the incidence of potential out-of-range physiological parameters, whether these are associated with altered postoperative outcome, and whether specific parameters or degrees of change are potential predictors of poor outcome
  • Identify variations in clinical practice across Europe

List of Chief investigator and Steering Committee members

Nicola Disma (Italy) – Chief Investigator, Karin Becke (Germany), Jurgen De Graaff (Netherlands), Thomas Engelhardt (United Kingdom), Walid Habre (Switzerland), Tom Hansen (Denmark), Angela Pistorio (Italy), Dusica Simic (Serbia), Francis Veyckemans (Belgium), Laszlo Vutskits (Switzerland), Suellen Walker (United Kingdom), Marzena Zielinska (Poland). 


European Society of Anaesthesiology Clinical Trial Network

Contact email for more info => research@esaic.org