Publication : Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Prof Walid Habre, MD; Nicola Disma, MD; Katalin Virag, MSc; Karin Becke, MD; Tom G Hansen, MD; Martin Jöhr, MD; et al. Published:March 28, 2017DOI:https://doi.org/10.1016/S2213-2600(17)30116-9


Study selected by ESAIC Research Committee: February 2013

Study protocol v1.3: 16 July 2014

Call for Centres: 01 June 2013 to 28 February 2014

Study CRF v1.4: 28 March 2014

Study eCRF v1.1: 28 March 2014

Recruitment of patients: April 2014 – December 2014

Data Cleaning: November 2014 to March 2016

Data analysis: April-May 2016

Manuscript writing: June-July 2016

Paper Submission: August 2016

Paper Publication: End 2016


The aims of the APRICOT study are:

  • To establish the incidence of severe critical events in children undergoing anaesthesia in Europe.
  • To describe the differences in paediatric anaesthesia practise throughout Europe.
  • To study the potential impact of this variability on the occurrence of severe critical events (e.g.: laryngospasm, bronchospasm, aspiration, anaphylaxis, cardiovascular instability, neurological damage and cardiac arrest…).


List of Chief investigator and Steering Committee members

(Chief Investigator)
Geneva University Children’s Hospital
Department APSI
Rue Willy Donzé, 6
CH-1205, Geneva, Switzerland
Karin BECKE Cnopf’sche Kinderklinik/Klinik Hallerwiese
Abteilung für Anästhesie und Intensivmedizin
St. Johannis-Mühlgasse, 19
DE-90419 Nürnberg, Germany
Krisztina BODA
(Study Statistician)
University of Szeged
Department of Medical Physics and Informatics
Korányi fasor, 9
HU-6726 Szeged, Hungary
Nicola DISMA Instituto Giannina Gaslini
Department of Pediatric Anesthesia
Via G Gaslini, 5
IT-6100 Genoa, Italy
Tom HANSEN Odense University Hospital
Department of Anaesthesia and Intensive Care
Sdr. Boulevard 29
DK-5000 Odense, Denmark
Martin JÖHR
Anästhesie Kinderspital
Institut für Anästhesie, Chir. Intensivmedizin, Rettungsmedizin und Schmerztherapie (IFAIRS)
Luzerner Kantonsspital
(co-Chief Investigator)
Cliniques Universitaires St Luc
Department Anaesthesiology
Avenue Hippocrate, 10-1821
BE-1200 Brussels, Belgium
Neil MORTON Royal Hospital For Sick Children
Department of Anaesthesia
Glasgow, G3 8SJ, United Kingdom
Ehrenfried SCHINDLER Asklepios Klinik Sankt Augustin GmbH
Department of Paediatric Anaesthesia
Arnold-Janssen-Straße 29
DE-53757 Sankt Augustin, Germany
Elly VERMEULEN Maastricht University Medical Center MUMC
Department of Anaesthesiology
P. De Byelaan 25
NL-6202 AZ Maastricht, The Netherlands
Marzena ZIELINSKA Clinical University Hospital
Department of Anaesthesiology and Intensive Care
Borowska 213
PL-50-556 Wroclaw, Poland



The study is sponsored by a grant of the European Society of Anaesthesiology Clinical Trial Network (ESAIC CTN).

Contact email for more info => research@esaic.org

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