Chief Investigator

Prof. Max Bell (Associate Professor, Senior Lecturer, Department of Perioperative Medicine and Surgical services, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet)

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ENCORE Short summary

National Coordinator

Are you interested in being:

  1. National Coordinator (NC) for your country? Please read Protocol below and then send your CV with your CTN experience and the number of centre you think you can recruit in your country to encore@esaic.org. If we do not have an NC for your country and you have previously participated in ESAIC CTN studies, we will contact you soon.

We will then advise you of the benefits and commitments of being an NC via email. Please note that all NCs and PIs will be authors of publications arising from ENCORE as discussed in details in the protocol, section 9.1.


  • Call for centre: Ongoing
  • Recruitment of patients: Foreseen for 2021


Study Objectives

The main objective of this international, observational study is to determine if anaesthesia technique (epidural vs no epidural or inhalational vs total intravenous) or surgical technique (laparoscopic vs open surgery) has any benefits for patients in term of the earlier start of adjuvant chemotherapy and improved short- or long-term outcomes in patients undergoing surgery for colorectal cancer (stage I-III).

Join the Study

This study will include as many participating institutions as possible across the world. It is planned to recruit at least 10,000 patients.

Would your hospital like to join this study as an actively contributing research centre? The ‘Call for Centres form’ must be filled in online. The completion of this form will facilitate coordination and is mandatory for participation in ESAIC CTN. ESAIC Secretariat will then contact you, providing you with additional information. Please visit the call for centres page. Once you register your centre, you will be asked to complete the pre-study survey that will allow the selection of the eligible centres.

Study Documents 

ENCORE protocol v1.0 21DEC20

ENCORE Appendix 1 – Study Synopsis v1.0 21DEC20

ENCORE Appendix 3 – Pre-Study Questionnaire for participation in the ENCORE trial v1.0 21DEC20

ENCORE Appendix 4 – Approval Documentation Coversheet v1.0 21DEC20

ENCORE Appendix 5 – Case Report Form v0.5 21DEC20

ENCORE Appendix 6 – Confidential Patient Logsheet v1.0 21DEC20

ENCORE Appendix 7 – End of study Reporting Form v1.0 21DEC20

ENCORE Appendix 8 – Staging of colorectal cancer v1.0 21DEC20

ENCORE Appendix 9 – Definitions v1.0 21DEC20

ENCORE Appendix 10 – Clavien Dindo Classification v1.0 21DEC20

ENCORE Appendix 11 – ASA-Physical status Classification v1.0 21DEC20

ENCORE Appendix 12 – M-DASI 4 q v1.0 21DEC20

ENCORE Appendix 13 – Postoperative complications v1.0 21DEC20

ENCORE Appendix 14 – Authorship policy v1.0 21DEC20

ENCORE Appendix 15 – Data Protection Overview v1.0 21DEC20

ENCORE Appendix 16 – Lawfulness of processing of data – GDPR v1.0 21DEC20


Steering Committee

  • Max Bell, Associate Professor, Senior Lecturer, Department of Perioperative Medicine and Surgical services, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet (CI)
  • Anil Gupta, Associate Professor, Karolinska University Hospital, Solna, Sweden
  • Christian Buchli, MD, PhD, Karolinska University Hospital, Solna, Sweden; K1 Department of Molecular Medicine and Surgery
  • Daniel Brattström, MD, PhD, Senior Consultant, Stockholm County Council, Oncologist
  • Mats Enlund, Associate Professor, Department of Anaesthesia, Västerås Hospital, affiliated with Uppsala University Hospital
  • Shaman Jhanji, MD, anaesthetist and intensivist at the Royal Marsden Hospital in London, UK
  • Bernhard Riedel, Professor, Director of Anaesthesia at Peter MacCallum Cancer Centre, Sydney, Australia
  • Antje Gottschalk, MD, PhD, Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany
  • Donal Buggy, Professor of Anaesthesiology & Perioperative Medicine, Mater University Hospital, School of Medicine, University College Dublin, Ireland; Consultant in Anaesthesiology & Perioperative Medicine, Mater University Hospital & Mater Private Hospital, Dublin, Ireland
  • Helene Beloeil, Professor of Professor of Anesthesiology Critical Care Medicine and Perioperative MedicineRennes University Hospital and School of Medicine, CHU de Rennes, France
  • Fredrik Granath, Associate Professor, Senior Lecturer, Biostatistician, Karolinska University Hospital, Solna, Sweden; K2 Department of Medicine, Solna
  • Hans de Boer, Anesthesiologist and Pain SpecialistDepartment of Anesthesiology Pain Medicine and Procedural Sedation and AnalgesiaMartini General Hospital Groningen, The Netherlands (As a representative member of the ESAIC Research Committee)


The study is entirely sponsored by a grant from the European Society of Anaesthesiology and Intensive Care Clinical Trial Network (ESAIC CTN). The ESAIC CTN provides an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.


Endorsements and Supports

The ENCORE Study is proud to announce its endorsement by:

Finland; The Finnish Society of Anaesthesiologists https://www.say.fi/
Austria; Austrian Society for anaesthesiology and intensive care https://www.oegari.at/
Moldova; Society of Anaesthesia and Reanimatology of the Republic of Moldova https://ati.md/
Sweden; SFAI Swedish Society of Anaesthesia and Intensive Care https://sfai.se/
Portugal; the Portuguese Society of Anesthesiology www.spanestesiologia.pt


France; SFAR French society of anesthesia critical care and perioperative medicine https://sfar.org/
Germany; DGAI

German Society of Anaesthesiology and Intensive Care



Greece; Hellenic Society of Anaesthesiology  



Russia; Russian Federation of Anesthesiologists and Reanimatologists (FAR)  




Association of Anesthesiologists and Intensivists of Serbia




Turkey; The Turkish Society of Anaesthesiology and Reanimation https://www.tard.org.tr/
Malta; Association of Anaesthesiologists of Malta http://aam-malta.org/
South African Society of Anaesthesiologists www.sasaweb.com


Do you want to endorse or support our study too? Please contact us at encore@esaic.org

Contact us

European Society of Anaesthesiology and Intensive Care

Rue des Comédiens 24
1000 Brussels, Belgium
T: +32 2 743 32 94 / +32 2 210 94 14
F: +32 2 743 32 98
E: research@esaic.org