Chief Investigator

Prof. Max Bell (Associate Professor, Senior Lecturer, Department of Perioperative Medicine and Surgical services, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet)



  • Call for centre: Ongoing
  • Recruitment of patients: Foreseen for 2021


Study Objectives

The main objective of this international, observational study is to determine if anaesthesia technique (epidural vs no epidural or inhalational vs total intravenous) or surgical technique (laparoscopic vs open surgery) has any benefits for patients in term of the earlier start of adjuvant chemotherapy and improved short- or long-term outcomes in patients undergoing surgery for colorectal cancer (stage I-III).


Join the Study

This study will include as many participating institutions as possible across the world. It is planned to recruit at least 10,000 patients.

Would your hospital like to join this study as an actively contributing research centre? The ‘Call for Centres form’ must be filled in online. The completion of this form will facilitate coordination and is mandatory for participation in ESAIC CTN. ESAIC Secretariat will then contact you, providing you with additional information. Please visit the call for centres page. Once you register your centre, you will be asked to complete the pre-study survey that will allow the selection of the eligible centres.


Like more detail?

ENCORE Flyer v. 1.1 – 19 August 2020


Steering Committee

  • Max Bell, Associate Professor, Senior Lecturer, Department of Perioperative Medicine and Surgical services, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet (CI)
  • Anil Gupta, Associate Professor, Karolinska University Hospital, Solna, Sweden
  • Christian Buchli, MD, PhD, Karolinska University Hospital, Solna, Sweden; K1 Department of Molecular Medicine and Surgery
  • Daniel Brattström, MD, PhD, Senior Consultant, Stockholm County Council, Oncologist
  • Mats Enlund, Associate Professor, Department of Anaesthesia, Västerås Hospital, affiliated with Uppsala University Hospital
  • Shaman Jhanji, MD, anaesthetist and intensivist at the Royal Marsden Hospital in London, UK
  • Bernhard Riedel, Professor, Director of Anaesthesia at Peter MacCallum Cancer Centre, Sydney, Australia
  • Antje Gottschalk, MD, PhD, Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany
  • Donal Buggy, Professor of Anaesthesiology & Perioperative Medicine, Mater University Hospital, School of Medicine, University College Dublin, Ireland; Consultant in Anaesthesiology & Perioperative Medicine, Mater University Hospital & Mater Private Hospital, Dublin, Ireland
  • Helene Beloeil, Professor of Professor of Anesthesiology Critical Care Medicine and Perioperative MedicineRennes University Hospital and School of Medicine, CHU de Rennes, France
  • Fredrik Granath, Associate Professor, Senior Lecturer, Biostatistician, Karolinska University Hospital, Solna, Sweden; K2 Department of Medicine, Solna
  • Hans de Boer, Anesthesiologist and Pain SpecialistDepartment of Anesthesiology Pain Medicine and Procedural Sedation and AnalgesiaMartini General Hospital Groningen, The Netherlands (As a representative member of the ESAIC Research Committee)


National Coordinating Investigators

The ESAIC Secretariat and Steering Committee is looking for National Coordinating Investigators to support the conduction of The-ENCORE Study, if you are interested, please contact us at encore@esaic.org.



The study is entirely sponsored by a grant from the European Society of Anaesthesiology Clinical Trial Network (ESAIC CTN). The ESAIC CTN provides an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.


Endorsements and Supports

The ENCORE Study is proud to announce its endorsement by:

Germany; DGAI

German Society of Anaesthesiology and Intensive Care



Greece; Hellenic Society of Anaesthesiology  



Russia; Russian Federation of Anesthesiologists and Reanimatologists (FAR)  




Association of Anesthesiologists and Intensivists of Serbia




Turkey; The Turkish Society of Anaesthesiology and Reanimation https://www.tard.org.tr/


Malta; Association of Anaesthesiologists of Malta http://aam-malta.org/



Do you want to endorse or support our study too? Please contact us at encore@esaic.org

Contact us

European Society of Anaesthesiology

Rue des Comédiens 24
1000 Brussels, Belgium
T: +32 2 743 32 94 / +32 2 210 94 14
F: +32 2 743 32 98
E: research@esaic.org