Dear investigator,

Thank you for your interest in the ENCORE Study.

The study will start recruitment on 1 December 2021, although centres can start after this date when they have all the necessary approvals in place.

Prior to recruitment, there are several steps to complete. Once all the steps are final and we are aware of your starting date, we will send you the access for the eCRF in OpenClinica.

NOTE : Principal Investigator must be a qualified doctor and all documents must be signed by the PI.

Mandatory steps before starting recruitment :

  1. Be listed on the list of participating Centres
  2. Complete the pre-study survey (1x per site)
  3. Use validated patient docs Translation – if your country is not in there, or you are missing a document, please contact your National Coordinator.
  4. Approval docs : Each centre must send 2 things :
    1. Approval Coversheet and
    2. Letter of approval/notification receipt from ethics/local authorizing body available
  1. Send names and emails of eCRF users: Max 3 persons with eCRF profiles per hospital. Investigator user profile+ 2 data-entry users (provide first name, last name and email addresses)

    *eCRF users will have access to the electronic data capture system but this does not mean they will be included as collaborators in publications. PIs will provide the list of collaborators at the same time as the ‘End of study report’ (i.e. at the end of the site’ recruitment). Please refer to the Authorship Policy for details about who are named in the publications.

  1. Sign the protocol signature page (page 2)
  1. Sign the Data Processing/Transfer Agreement : Please contact us to have the specific document required for your country

Chief Investigator

Prof. Max Bell (Associate Professor, Senior Lecturer, Department of Perioperative Medicine and Surgical services, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet)

Like more detail?

ENCORE Short summary



  • Call for centre: Ongoing
  • Start of patient recruitment: 1 December 2021


Study Objectives

The main objective of this international, observational study is to determine if anaesthesia technique (epidural vs no epidural or inhalational vs total intravenous) or surgical technique (laparoscopic vs open surgery) has any benefits for patients in term of the earlier start of adjuvant chemotherapy and improved short- or long-term outcomes in patients undergoing surgery for colorectal cancer (stage I-III).


Steering Committee

  • Max Bell, Associate Professor, Senior Lecturer, Department of Perioperative Medicine and Surgical services, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet (CI)
  • Anil Gupta, Associate Professor, Karolinska University Hospital, Solna, Sweden
  • Christian Buchli, MD, PhD, Karolinska University Hospital, Solna, Sweden; K1 Department of Molecular Medicine and Surgery
  • Daniel Brattström, MD, PhD, Senior Consultant, Stockholm County Council, Oncologist
  • Mats Enlund, Associate Professor, Department of Anaesthesia, VĂ€sterĂ„s Hospital, affiliated with Uppsala University Hospital
  • Shaman Jhanji, MD, anaesthetist and intensivist at the Royal Marsden Hospital in London, UK
  • Bernhard Riedel, Professor, Director of Anaesthesia at Peter MacCallum Cancer Centre, Sydney, Australia
  • Antje Gottschalk, MD, PhD, Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital MĂŒnster, MĂŒnster, Germany
  • Donal Buggy, Professor of Anaesthesiology & Perioperative Medicine, Mater University Hospital, School of Medicine, University College Dublin, Ireland; Consultant in Anaesthesiology & Perioperative Medicine, Mater University Hospital & Mater Private Hospital, Dublin, Ireland
  • Helene Beloeil, Professor of Professor of Anesthesiology Critical Care Medicine and Perioperative Medicine, Rennes University Hospital and School of Medicine, CHU de Rennes, France
  • Fredrik Granath, Associate Professor, Senior Lecturer, Biostatistician, Karolinska University Hospital, Solna, Sweden; K2 Department of Medicine, Solna
  • Hans de Boer, Anesthesiologist and Pain Specialist, Department of Anesthesiology Pain Medicine and Procedural Sedation and Analgesia, Martini General Hospital Groningen, The Netherlands (As a representative member of the ESAIC Research Committee)

Participating countries


The study is entirely sponsored by a grant from the European Society of Anaesthesiology and Intensive Care Clinical Trial Network (ESAIC CTN). The ESAIC CTN provides an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.

Join the study

This study will recruit as many participating institutions as possible around the world. It is planned to enrol at least 10,000 patients from a minimum of 200 centres.

Would your hospital like to join this study as an actively contributing research centre? The ‘Call for Centres form’ must be filled in online. The completion of this form will facilitate coordination and is mandatory for participation in ESAIC CTN. ESAIC Secretariat will then contact you providing you with additional information.

Join the study

Contact us

European Society of Anaesthesiology and Intensive Care

Rue des Comédiens 24
1000 Brussels, Belgium
T: +32 2 743 32 94 / +32 2 210 94 14
F: +32 2 743 32 98